For the treatment and prevention of tick , flea and mite infestations in dogs. Bravecto® Spot-On is well tolerated in MDR1 dogs. Wenn die Tablette vom Hund nicht freiwillig aufgenommen wird, kann sie auch mit dem Futter oder direkt ins Maul verabreicht werden. Treatment with Bravecto may begin at any time of the year and can continue year round without interruption. Product may be supplied in 1 or 2 tubes per carton. The dogs in the control group (0X) were administered saline orally. Hold the tube at the crimped end with the cap in an upright position (tip up). Indications: Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infes- Find the size that’s right for your pet. Applying is easy. Step 3: Squeeze the tube and gently apply Bravecto in one or more spots starting between the shoulder blades and continuing along the dog’s back. The tube is open and ready for application when a breaking of the seal is felt. Bravecto® provides 12 weeks of protection against fleas and ticks in dogs with the tasty Chew. Percentage of Dogs with Adverse Reactions in the Field Study, Bravecto Group: Percentage of Dogs with the AR During the 105-Day Study, Active Control Group: Percentage of Dogs with the AR During the 84-Day Study. Bravecto® provides 12 weeks of protection against fleas and ticks in dogs with the tasty Chew. Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis(black-legged tick), Dermacentor variabilis(American dog tick), and Rhipicephalus sanguineus(brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. 2017-07-12T12:56:09-04:00 PDF/X-1:2001 proof:pdf During veterinary examination at Week 7, two pups from the control group had inguinal testicles, and two and four pups from the treated group had inguinal and cryptorchid testicles, respectively. In dogs older than 8 weeks, treatment every 2 months has been shown to be well … Free Shipping over $39. Bravecto has been approved for use in breeding, pregnant, and lactating female dogs. Adobe InDesign CC 2015 (Macintosh) %PDF-1.3 %���� Updated: 2020-11-27. Bravecto Kautabletten zum oder um den Zeitpunkt der Fütterung verabreichen. Part the fur at the administration site. False For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. One dog treated with Bravecto was observed by the owner to be off balance for about 30 minutes five days after its first dose and had no similar observations after the second dose. Bravecto is available in five strengths for use in dogs (112.5, 250, 500, 1000, and 1400 mg fluralaner per tube). Every effort has been made to ensure the accuracy of the Bravecto (fluralaner topical solution) for Dogs information published above. There are no known contraindications for the use of the product. ��, 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. Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. CPN:1208298.2 Available in three strengths with an easy to use applicator. BRAVECTO (Fluralaner Topical Solution) is available in five strengths for use in dogs (112.5 mg, 250 mg, 500 mg, 1000 mg, and 1400 mg fluralaner per tube). To obtain maximum flea control, it is recommended that all cats and dogs in the same environment are treated. Distributed by: Intervet, Inc., (d/b/a Merck Animal Health), Madison, NJ 07940. 1,2,17 No adverse effects with Bravecto Chew for Dogs in MDR-1 gene-deficient collies at 3x the recommended … In a well-controlled U.S. field study, which included a total of 165 households and 321 treated dogs (221 with fluralaner and 100 with a topical active control), there were no serious adverse reactions. Dogs with signs of flea allergy dermatitis showed improvement in erythema, alopecia, papules, scales, crusts, and excoriation as a direct result of eliminating flea infestations. H��W[sۺ~׌���I �y�L'm�i{z��y�2��$ּ�������%��X�i�`��o{�8����8{�����V��n��E_f�I�xf�e2`�9��lVN��5we�7I�T�a]��Ӥ`m]�]^W�)[� ��W�t�o-����GZhH2�8;-\f������2@6������5��[lT�+�(��]V/YŠ�M���U{R�j�*i�rN%XGpOC߫6m��E���l��=��I�f]�P*���/�pPl��Oy��F�Wyٗ,��+�S�]'f���X�P�����]�ٖ=�|���ʼ(�"� l�}�gh-f�@ZW]�W-�$~쮩0��wl�/�,e��C1���{�ҵ*�s��T���BĂ�|j{��o�-y��Y�����7kUm��t~c�|�oc�TݚvlO_o�����G�{]��&��nf�m����i~��� Free Shipping over $39. Avoid contact with skin and eyes. The dog was started on antiepileptic medication and had no additional seizures during the study. The dogs in the control group (0X) were untreated. :n���E{#�������:��.�A������-�쑞,��j8A/�/T�;�d�a_�$��'x�Z5������,ˍ�I�:}�vj�Y#O�F2-�X�b��˾��[\�w;��k� WARNINGS Human Warnings: Not for human use. Bravecto may be administered every 8 weeks in case of potential exposure to Dermacentor variabilis ticks (see Effectiveness). Stop a flea infestation with the mighty killing ... Plus, it works non-stop for 30 days on dogs and cats. Bravecto is not effective against lone star ticks beyond 8 weeks of dosing. References: 1. xmp.id:7c5f6bcd-df26-4d51-89d6-297831264b00 The dog should be observed during administration to confirm that the tablet is swallowed. PDF/X-1a:2001 BRAVECTO Topical Solution for Dogs: The most commonly reported adverse reactions include vomiting, hair loss, diarrhea, lethargy, decreased appetite, and moist dermatitis/rash. 1,2 The Bravecto® Spot-On in dogs provides 4 months of tick protection and 6 months of flea protection. Bravecto ist eine Kautablette und wird von den meisten Hunden gut angenommen. Bravecto gives your cat protection against fleas and black-legged ticks (deer ticks) for 12 weeks, and dog ticks for 8 weeks. Administer Bravecto chewable tablets at or around the time of feeding. Product may be supplied in 1 or 2 tubes per box. BRAVECTO PLUS has not been shown to be effective for 2 months in kittens less than 6 months of age. In a European laboratory study, Bravecto demonstrated ≥98.2% effectiveness against fleas and Ixodes ricinus ticks after multiple water immersion or shampooing occasions, the first occurring 3 days after application, for 12 weeks. Do not contact or allow children to contact the application site until dry. In cats, Bravecto® Spot On provides 3 months of protection against fleas and ticks. Bravecto is not effective against lone star ticks beyond 8 weeks of dosing. Place the tube tip vertically against the skin between the shoulder blades of the dog. Bravecto Topical Solution for Dogs kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [ Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and … The product is highly flammable. One dog had two seizures a day apart about 18 days after its first dose. Adobe InDesign CC 2015 (Macintosh) Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Ships fast. The fluoxetine was discontinued and the dog experienced no additional seizures during the study. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Dosage and Administration: Bravecto should be administered orally as a single dose every 12 weeks according to the Dosage Schedule Store in the original package in order to protect from moisture. Bravecto should be administered topically as a single dose every 12 weeks according to the Dosage Schedule below to provide a minimum dose of 11.4 mg/lb (25 mg/kg) body weight. / or greater. UniversLTStd-Light 2017-07-12T12:56:12-04:00 One treated animal experienced loose feces with blood three hours after administration. 1 Intervet Canada Corp., subsidiary of Merck & Co., Inc., 16750, route Transcanadienne, Kirkland, QC H9H 4M7 1 866 683-7838 Version: 21FEB2019 ®Intervet International B.V. Used under license. RotisSansSerif-Light BRAVECTO ® SPOT-ON Reg. For optimal control of tick and flea infestation, the Bravecto chewable tablet should be administered at 3 monthly intervals. from application/x-indesign to application/pdf Fluralaner is for systemic use and belongs to the class of isoxazoline-substituted benzamide derivatives. Watch the slide show to learn how easy it is to apply FRONTLINE Plus onto your pet. Dosage and Administration: Bravecto should be administered topically as a single dose every 12 weeks according to the Dosage Schedulebelow to provide a minimum dose of 18.2 mg/lb (40 mg/kg) body weight. In a well-controlled laboratory studies, Bravecto killed fleas and reduced the numbers of live fleas on dogs by >99% and 100% within 24 and 48 hours, respectively, post-infestation for 12 weeks. xmp.did:A6150B3F132068118083C6B6E3A95A4D The Human reports represent 8.73% of cases for all species. xmp.iid:7da3e8c6-2630-4728-ae36-d44b4de60640 1,2 Bravecto is safe to use and efficacious in adult dogs and puppies over 6 months of age and weighing 4.4 lb. Kills fleas and ticks For dogs and puppies 6 months of age and older Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. If contact with eyes occurs, then flush eyes slowly and gently with water. Topical flea and tick control kills for 30 days. Cosmetic changes at the application site included matting/clumping/spiking of hair, wetness, or a greasy appearance. For topical use only. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, and urinalysis), gross pathology, histopathology, or organ weights. Step 2: The dog should be standing or lying with its back horizontal during application. Avoid applying an excessive amount of solution in any one spot which may cause some solution to run or drip off of the dog. BRAVECTO ® (fluralaner) Topical Solution >88-123 lb 1 Tube. BRAVECTO PLUS reducesthe flea challenge experienced by the animaland aids in the treatment strategy for flea allergy dermatitis. The cap is designed to stay on the tube for dosing and should not be removed. Ships Free . Select one or more newsletters to continue. RotisSansSerif-LightItalic The Bravecto topical solution for dogs and cats is included in the report mentioned in this story. Do not contact or allow children to contact the application site until dry. PDF/X-1:2001 CONTENTS: 1 TUBE CONTAINING 1400 MGFLURALANER . There are no known contraindications for the use of the product. Each tube is packaged individually in a pouch. Avoid contact with skin and eyes. uuid:c31aeb85-d228-d84e-94db-e35d08d0e1f9 RotisSansSerif-Bold The safety of BRAVECTO PLUS has not been established in breeding, pregnant and lactating cats. DATE OF PUBLICATION OF THIS PACKAGE INSERT. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. Each milliliter contains 280 mg of fluralaner. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, and urinalysis), gross pathology, histopathology, or organ weights. In a well-controlled field study Bravecto was used concurrently with other medications, such as vaccines, anthelmintics, antibiotics, steroids and sedatives. Bravecto demonstrated ≥90% effectiveness against Amblyomma americanum 72 hours post-infestation for 8 weeks, but failed to demonstrate ≥90% effectiveness beyond 8 weeks. Abnormal salivation was observed on 17 occasions: in six treated dogs (11 occasions) after dosing and four control dogs (6 occasions). We comply with the HONcode standard for trustworthy health information -, Bravecto (fluralaner topical solution) for Dogs Indications, Warnings and cautions for Bravecto (fluralaner topical solution) for Dogs, Direction and dosage information for Bravecto (fluralaner topical solution) for Dogs. BRAVECTO Topical Solution 500 mg Indications. (fluralaner topical solution) for Dogs BRIEF SUMMARY (For full Prescribing Information, see package insert) Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. 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Fluralaner is a member of the isoxazoline class. Adobe PDF Library 15.0 Step 1: Immediately before use, open the pouch and remove the tube. In a well-controlled U.S. field study, a single dose of Bravecto reduced fleas by ≥99.8% for 12 weeks. Use caution in dogs with a history of seizures. The cap should be rotated clockwise or counter clockwise one full turn. Bravecto Plus should be administered topically as a single dose every 2 months according to the Dosage Schedule below to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. 2017-07-12T12:56:12-04:00 Do not eat, drink or smoke while handling the product. Each tube is packaged individually in a pouch. (see Animal Safety). Reported Human reactions after contact with Bravecto (Fluralaner parent chemical) Many members may not be aware there have been adverse reactions in humans after giving either the chewable or spot on. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Bravecto (fluralaner topical solution) for Dogs. Avoid oral ingestion. Bravecto (Fluralaner) is a Topical Solution for Dogs that kills fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks. For a copy of the Safety Data Sheet (SDS) or to report suspected adverse drug events, contact Merck Animal Health at 1-800-224-5318. Available for Android and iOS devices. Keep this and all drugs out of the reach of children. Bravecto is a prescription strength topical just for cats. In a European field study in cats, there were three reports of facial dermatitis in humans after close contact with the application site which occurred within 4 days of application. Bravecto is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Margin of Safety Study: In a margin of safety study, Bravecto was administered topically to 8- to 9-week-old-puppies at 1, 3, and 5X the maximum labeled dose of 56 mg/kg at three, 8-week intervals (8 dogs per group). Bravecto tablets were administered to intact, reproductively- sound male and female Beagles at a dose of up to 168 mg/kg (equivalent to 3X the maximum treatment dose) on three to four occasions at 8-week intervals. application/pdf (fluralaner topical solution) for Dogs BRIEF SUMMARY (For full Prescribing Information, see package insert) Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Bodyweight (kg) of dog: Bravecto 112.5 mg: Bravecto 250 mg: Bravecto 500 mg: Bravecto 1000 mg: Bravecto 1400 mg: 2* – 4.5: 1 > 4.5 – 10: 1 > 10 – 20: 1 > 20 – 40: 1 > 40 – 56: 1 *For use in dogs from 8 weeks of age and over 2kg. Avoid oral ingestion. Keep away from heat, sparks, open flame or other sources of ignition. For topical use only. If contact with eyes occurs, then flush eyes slowly and gentl… xmp.did:A6150B3F132068118083C6B6E3A95A4D If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into the mouth. Fluralaner is a member of the isoxazoline class. One adult treated dog suffered a seizure during the course of the study (46 days after the third treatment). 1,2 It has been tested and found safe in puppies at least 8 to 9 weeks of age at 5x the clinical dose. Inactive ingredients: dimethylacetamide, glycofurol, diethyltoluamide, acetone. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. FOR ANIMAL USE ONLY. As of November 1, 2020 there have been 1380 reports of human adverse reactions reported to the EMA. converted No undescended testicles were observed at the time of necropsy (days 50 to 71). Each chew is formulated to provide a minimum dose of 11.4 mg/lb (25 mg/kg) body weight.The chemical name of fluralaner is (±) - 4 - [5 - (3,5 - dichlorophenyl) - 5 - (trifluoromethyl) - 4,5 - dihydroisoxazol - 3 - yl] - 2 - methyl - N - [2 - oxo - 2 - (2,2,2 - trifluoroethylamino) ethyl]benzamide. 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